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BDBM545168 US11286268, Compound 654

SMILES: Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(cc(C#N)c3c2=O)-c2cccnc2)c2scc(C(O)=O)c2n1

InChI Key: InChIKey=BBDSESVJPCHQJU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545168   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545168
PNG
(US11286268, Compound 654)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(cc(C#N)c3c2=O)-c2cccnc2)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C32H22ClN5O4S/c1-17-10-24(30-29(36-17)25(16-43-30)32(40)41)23-13-22(33)5-6-27(23)42-9-8-38-18(2)37-26-12-20(19-4-3-7-35-15-19)11-21(14-34)28(26)31(38)39/h3-7,10-13,15-16H,8-9H2,1-2H3,(H,40,41)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 3.12n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair