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BDBM545209 US11286268, Compound 695

SMILES: Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(Cl)c(O)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1

InChI Key: InChIKey=SRJXNAXEPLBXOE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545209   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545209
PNG
(US11286268, Compound 695)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(Cl)c(O)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C27H18Cl2N4O5S/c1-12-7-16(25-23(31-12)18(11-39-25)27(36)37)15-8-14(28)3-4-21(15)38-6-5-33-13(2)32-20-9-19(29)24(34)17(10-30)22(20)26(33)35/h3-4,7-9,11,34H,5-6H2,1-2H3,(H,36,37)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.05n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair