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BDBM545217 US11286268, Compound 703

SMILES: Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(Cl)c(N4CC(C)(CO)C4)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1

InChI Key: InChIKey=VZIKBXFNYHSJBV-UHFFFAOYSA-N

Data: 1 IC50

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Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545217   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545217
PNG
(US11286268, Compound 703)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(Cl)c(N4CC(C)(CO)C4)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C32H27Cl2N5O5S/c1-16-8-20(29-27(36-16)22(12-45-29)31(42)43)19-9-18(33)4-5-25(19)44-7-6-39-17(2)37-24-10-23(34)28(21(11-35)26(24)30(39)41)38-13-32(3,14-38)15-40/h4-5,8-10,12,40H,6-7,13-15H2,1-3H3,(H,42,43)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 3.18n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair