BDBM545293 US11286268, Compound 781

SMILES: CN(C)C(=O)c1nc2c(cc1C(F)(F)F)nc(C)n(CCOc1ccc(Cl)cc1-c1cc(C)nc3c(csc13)C(O)=O)c2=O

InChI Key: InChIKey=QGIBKNRSIIKYAA-UHFFFAOYSA-N

Data: 1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545293   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic translation initiation factor 4E-binding protein 1 (Homo sapiens (Human))	BDBM545293 (US11286268, Compound 781) Show SMILES CN(C)C(=O)c1nc2c(cc1C(F)(F)F)nc(C)n(CCOc1ccc(Cl)cc1-c1cc(C)nc3c(csc13)C(O)=O)c2=O Show InChI InChI=1S/C29H23ClF3N5O5S/c1-13-9-17(25-22(34-13)18(12-44-25)28(41)42)16-10-15(30)5-6-21(16)43-8-7-38-14(2)35-20-11-19(29(31,32)33)23(26(39)37(3)4)36-24(20)27(38)40/h5-6,9-12H,7-8H2,1-4H3,(H,41,42)	PDB KEGG UniProtKB/SwissProt GoogleScholar	UniChem	US Patent	n/a	n/a	3.12	n/a	n/a	n/a	n/a	n/a	n/a
eFFECTOR Therapeutics, Inc. US Patent					Assay Description eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...				US Patent US11286268 (2022)
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