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BDBM545305 US11286268, Compound 792

SMILES: Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cnc(Cl)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1

InChI Key: InChIKey=XSGSXPXUPVXDEX-UHFFFAOYSA-N

Data: 1 IC50

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Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545305   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545305
PNG
(US11286268, Compound 792)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cnc(Cl)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C26H17Cl2N5O4S/c1-12-7-16(23-22(31-12)18(11-38-23)26(35)36)15-8-14(27)3-4-20(15)37-6-5-33-13(2)32-19-10-30-24(28)17(9-29)21(19)25(33)34/h3-4,7-8,10-11H,5-6H2,1-2H3,(H,35,36)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 2.44n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair