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BDBM545307 US11286268, Compound 794

SMILES: Cc1ccc(-c2cc(Cl)ccc2OCCn2c(C)nc3cnc(C4CC4)c(C#N)c3c2=O)c2scc(C(O)=O)c12

InChI Key: InChIKey=CTDSXAKPVPXRNR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545307   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545307
PNG
(US11286268, Compound 794)
Show SMILES Cc1ccc(-c2cc(Cl)ccc2OCCn2c(C)nc3cnc(C4CC4)c(C#N)c3c2=O)c2scc(C(O)=O)c12
Show InChI InChI=1S/C30H23ClN4O4S/c1-15-3-7-19(28-25(15)22(14-40-28)30(37)38)20-11-18(31)6-8-24(20)39-10-9-35-16(2)34-23-13-33-27(17-4-5-17)21(12-32)26(23)29(35)36/h3,6-8,11,13-14,17H,4-5,9-10H2,1-2H3,(H,37,38)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 3.41n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair