BDBM545309 US11286268, Compound 796

SMILES: Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(c(nc3c2=O)N2CC(=O)C2)C(F)(F)F)c2scc(C(O)=O)c2n1

InChI Key: InChIKey=WKKYSHJSCJXCKL-UHFFFAOYSA-N

Data: 1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545309   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic translation initiation factor 4E-binding protein 1 (Homo sapiens (Human))	BDBM545309 (US11286268, Compound 796) Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(c(nc3c2=O)N2CC(=O)C2)C(F)(F)F)c2scc(C(O)=O)c2n1 Show InChI InChI=1S/C29H21ClF3N5O5S/c1-13-7-18(25-23(34-13)19(12-44-25)28(41)42)17-8-15(30)3-4-22(17)43-6-5-38-14(2)35-21-9-20(29(31,32)33)26(36-24(21)27(38)40)37-10-16(39)11-37/h3-4,7-9,12H,5-6,10-11H2,1-2H3,(H,41,42)	PDB KEGG UniProtKB/SwissProt GoogleScholar	UniChem	US Patent	n/a	n/a	3.27	n/a	n/a	n/a	n/a	n/a	n/a
eFFECTOR Therapeutics, Inc. US Patent					Assay Description eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...				US Patent US11286268 (2022)
					More data for this Ligand-Target Pair