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BDBM545309 US11286268, Compound 796

SMILES: Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(c(nc3c2=O)N2CC(=O)C2)C(F)(F)F)c2scc(C(O)=O)c2n1

InChI Key: InChIKey=WKKYSHJSCJXCKL-UHFFFAOYSA-N

Data: 1 IC50

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Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545309   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545309
PNG
(US11286268, Compound 796)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(c(nc3c2=O)N2CC(=O)C2)C(F)(F)F)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C29H21ClF3N5O5S/c1-13-7-18(25-23(34-13)19(12-44-25)28(41)42)17-8-15(30)3-4-22(17)43-6-5-38-14(2)35-21-9-20(29(31,32)33)26(36-24(21)27(38)40)37-10-16(39)11-37/h3-4,7-9,12H,5-6,10-11H2,1-2H3,(H,41,42)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 3.27n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair