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BDBM545319 US11286268, Compound 806

SMILES: CN(C)Cc1cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cccc(c3)C(O)=O)c(=O)c2c(C#N)c1OC(F)F

InChI Key: InChIKey=GWEAQKRTNJKBMK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545319   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545319
PNG
(US11286268, Compound 806)
Show SMILES CN(C)Cc1cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cccc(c3)C(O)=O)c(=O)c2c(C#N)c1OC(F)F
Show InChI InChI=1S/C29H25ClF2N4O5/c1-16-34-23-12-19(15-35(2)3)26(41-29(31)32)22(14-33)25(23)27(37)36(16)9-10-40-24-8-7-20(30)13-21(24)17-5-4-6-18(11-17)28(38)39/h4-8,11-13,29H,9-10,15H2,1-3H3,(H,38,39)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 3.58n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair