BDBM545327 US11286268, Compound 815

SMILES: CN1CCN(CC1(C)C)c1ncc2nc(C)n(CCOc3ccc(Cl)cc3-c3ccnc4c(csc34)C(O)=O)c(=O)c2c1C#N

InChI Key: InChIKey=RZPQSVOVLQUAGZ-UHFFFAOYSA-N

Data: 1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545327   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic translation initiation factor 4E-binding protein 1 (Homo sapiens (Human))	BDBM545327 (US11286268, Compound 815) Show SMILES CN1CCN(CC1(C)C)c1ncc2nc(C)n(CCOc3ccc(Cl)cc3-c3ccnc4c(csc34)C(O)=O)c(=O)c2c1C#N Show InChI InChI=1S/C32H30ClN7O4S/c1-18-37-24-15-36-29(39-10-9-38(4)32(2,3)17-39)22(14-34)26(24)30(41)40(18)11-12-44-25-6-5-19(33)13-21(25)20-7-8-35-27-23(31(42)43)16-45-28(20)27/h5-8,13,15-16H,9-12,17H2,1-4H3,(H,42,43)	PDB KEGG UniProtKB/SwissProt GoogleScholar	UniChem	US Patent	n/a	n/a	3.31	n/a	n/a	n/a	n/a	n/a	n/a
eFFECTOR Therapeutics, Inc. US Patent					Assay Description eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...				US Patent US11286268 (2022)
					More data for this Ligand-Target Pair