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BDBM545347 US11286268, Compound 836

SMILES: CN1CCN(CC1)c1c(cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4ccsc34)c(=O)c2c1C#N)C(F)(F)F

InChI Key: InChIKey=OCXORQMCKPAISW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545347   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545347
PNG
(US11286268, Compound 836)
Show SMILES CN1CCN(CC1)c1c(cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4ccsc34)c(=O)c2c1C#N)C(F)(F)F
Show InChI InChI=1S/C32H28ClF3N6O2S/c1-18-14-22(30-25(38-18)6-13-45-30)21-15-20(33)4-5-27(21)44-12-11-42-19(2)39-26-16-24(32(34,35)36)29(23(17-37)28(26)31(42)43)41-9-7-40(3)8-10-41/h4-6,13-16H,7-12H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 2.33n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair