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BDBM545407 US11286268, Compound 897

SMILES: COc1ncc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N

InChI Key: InChIKey=BPLHARBYYIXRFU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545407   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545407
PNG
(US11286268, Compound 897)
Show SMILES COc1ncc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N
Show InChI InChI=1S/C27H20ClN5O5S/c1-13-8-17(24-23(31-13)19(12-39-24)27(35)36)16-9-15(28)4-5-21(16)38-7-6-33-14(2)32-20-11-30-25(37-3)18(10-29)22(20)26(33)34/h4-5,8-9,11-12H,6-7H2,1-3H3,(H,35,36)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.40n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair