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BDBM545447 US11286268, Compound 938

SMILES: Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(c(nc3c2=O)C(C)(C)O)C(F)(F)F)c2scc(C(O)=O)c2n1

InChI Key: InChIKey=MJWXLKZSXRSCME-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545447   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545447
PNG
(US11286268, Compound 938)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(c(nc3c2=O)C(C)(C)O)C(F)(F)F)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C29H24ClF3N4O5S/c1-13-9-17(24-22(34-13)18(12-43-24)27(39)40)16-10-15(30)5-6-21(16)42-8-7-37-14(2)35-20-11-19(29(31,32)33)25(28(3,4)41)36-23(20)26(37)38/h5-6,9-12,41H,7-8H2,1-4H3,(H,39,40)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 2.44n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair