BindingDB logo
myBDB logout

BDBM545473 US11286268, Compound 964

SMILES: Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(c(-c4nc(C)ncc4F)c(C#N)c3c2=O)C(F)(F)F)c2scc(C(O)=O)c2n1

InChI Key: InChIKey=BVRXNRZQTFFMDM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545473   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545473
PNG
(US11286268, Compound 964)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(c(-c4nc(C)ncc4F)c(C#N)c3c2=O)C(F)(F)F)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C33H21ClF4N6O4S/c1-14-8-19(30-28(41-14)21(13-49-30)32(46)47)18-9-17(34)4-5-25(18)48-7-6-44-16(3)43-24-10-22(33(36,37)38)26(20(11-39)27(24)31(44)45)29-23(35)12-40-15(2)42-29/h4-5,8-10,12-13H,6-7H2,1-3H3,(H,46,47)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 3.32n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair