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BDBM545475 US11286268, Compound 966

SMILES: Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(c(-c4ncc(F)cn4)c(C#N)c3c2=O)C(F)(F)F)c2scc(C(O)=O)c2n1

InChI Key: InChIKey=PLRWWSCSACNNOY-UHFFFAOYSA-N

Data: 1 IC50

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Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545475   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545475
PNG
(US11286268, Compound 966)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(c(-c4ncc(F)cn4)c(C#N)c3c2=O)C(F)(F)F)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C32H19ClF4N6O4S/c1-14-7-19(28-27(41-14)21(13-48-28)31(45)46)18-8-16(33)3-4-24(18)47-6-5-43-15(2)42-23-9-22(32(35,36)37)25(20(10-38)26(23)30(43)44)29-39-11-17(34)12-40-29/h3-4,7-9,11-13H,5-6H2,1-2H3,(H,45,46)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 3.58n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair