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BDBM545511 US11286268, Compound 1002

SMILES: CN(C)c1ncc2cc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N

InChI Key: InChIKey=ZJMFTIZGXTZLRR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545511   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545511
PNG
(US11286268, Compound 1002)
Show SMILES CN(C)c1ncc2cc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N
Show InChI InChI=1S/C29H24ClN5O4S/c1-15-9-20(26-25(33-15)22(14-40-26)29(37)38)19-11-18(30)5-6-23(19)39-8-7-35-16(2)10-17-13-32-27(34(3)4)21(12-31)24(17)28(35)36/h5-6,9-11,13-14H,7-8H2,1-4H3,(H,37,38)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 2.37n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair