BDBM545578 US11286268, Compound 1069

SMILES: CCc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3c(C)nc(N)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1

InChI Key: InChIKey=JERNCBCPAGRWSN-UHFFFAOYSA-N

Data: 1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545578   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic translation initiation factor 4E-binding protein 1 (Homo sapiens (Human))	BDBM545578 (US11286268, Compound 1069) Show SMILES CCc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3c(C)nc(N)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1 Show InChI InChI=1S/C28H23ClN6O4S/c1-4-16-10-18(25-24(34-16)20(12-40-25)28(37)38)17-9-15(29)5-6-21(17)39-8-7-35-14(3)33-23-13(2)32-26(31)19(11-30)22(23)27(35)36/h5-6,9-10,12H,4,7-8H2,1-3H3,(H2,31,32)(H,37,38)	PDB KEGG UniProtKB/SwissProt GoogleScholar	UniChem	US Patent	n/a	n/a	1.52	n/a	n/a	n/a	n/a	n/a	n/a
eFFECTOR Therapeutics, Inc. US Patent					Assay Description eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...				US Patent US11286268 (2022)
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