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BDBM545661 US11286268, Compound 1152

SMILES: CO[C@H]1C[C@H](C1)c1ncc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N

InChI Key: InChIKey=UNRHAGMTYYITKV-IZAXUBKRSA-N

Data: 1 IC50

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Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545661   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545661
PNG
(US11286268, Compound 1152)
Show SMILES CO[C@H]1C[C@H](C1)c1ncc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N
Show InChI InChI=1S/C31H26ClN5O5S/c1-15-8-21(29-28(35-15)23(14-43-29)31(39)40)20-11-18(32)4-5-25(20)42-7-6-37-16(2)36-24-13-34-27(17-9-19(10-17)41-3)22(12-33)26(24)30(37)38/h4-5,8,11,13-14,17,19H,6-7,9-10H2,1-3H3,(H,39,40)/t17-,19+
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 3.80n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair