BDBM545661 US11286268, Compound 1152

SMILES: CO[C@H]1C[C@H](C1)c1ncc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N

InChI Key: InChIKey=UNRHAGMTYYITKV-IZAXUBKRSA-N

Data: 1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545661   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic translation initiation factor 4E-binding protein 1 (Homo sapiens (Human))	BDBM545661 (US11286268, Compound 1152) Show SMILES CO[C@H]1C[C@H](C1)c1ncc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N Show InChI InChI=1S/C31H26ClN5O5S/c1-15-8-21(29-28(35-15)23(14-43-29)31(39)40)20-11-18(32)4-5-25(20)42-7-6-37-16(2)36-24-13-34-27(17-9-19(10-17)41-3)22(12-33)26(24)30(37)38/h4-5,8,11,13-14,17,19H,6-7,9-10H2,1-3H3,(H,39,40)/t17-,19+	PDB KEGG UniProtKB/SwissProt GoogleScholar	UniChem	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
eFFECTOR Therapeutics, Inc. US Patent					Assay Description eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...				US Patent US11286268 (2022)
					More data for this Ligand-Target Pair