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BDBM545732 US11286268, Compound 1222

SMILES: CN1CCN(CC1)c1c(cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc(c3)C(O)=O)c(=O)c2c1C#N)C(F)(F)F

InChI Key: InChIKey=ICAMNOZDGZUMCE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545732   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545732
PNG
(US11286268, Compound 1222)
Show SMILES CN1CCN(CC1)c1c(cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc(c3)C(O)=O)c(=O)c2c1C#N)C(F)(F)F
Show InChI InChI=1S/C31H28ClF3N6O4/c1-17-12-19(13-25(37-17)30(43)44)21-14-20(32)4-5-26(21)45-11-10-41-18(2)38-24-15-23(31(33,34)35)28(22(16-36)27(24)29(41)42)40-8-6-39(3)7-9-40/h4-5,12-15H,6-11H2,1-3H3,(H,43,44)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 3.02n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair