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BDBM545735 US11286268, Compound 1225

SMILES: CN(C)c1cc(cc(n1)C(O)=O)-c1cc(Cl)ccc1OCCn1c(C)nc2cc(c(N3CCN(C)CC3)c(C#N)c2c1=O)C(F)(F)F

InChI Key: InChIKey=XCTVBBPOFIAZKK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545735   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545735
PNG
(US11286268, Compound 1225)
Show SMILES CN(C)c1cc(cc(n1)C(O)=O)-c1cc(Cl)ccc1OCCn1c(C)nc2cc(c(N3CCN(C)CC3)c(C#N)c2c1=O)C(F)(F)F
Show InChI InChI=1S/C32H31ClF3N7O4/c1-18-38-24-16-23(32(34,35)36)29(42-9-7-41(4)8-10-42)22(17-37)28(24)30(44)43(18)11-12-47-26-6-5-20(33)15-21(26)19-13-25(31(45)46)39-27(14-19)40(2)3/h5-6,13-16H,7-12H2,1-4H3,(H,45,46)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 3.12n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair