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BDBM546104 US11286268, Compound 1603

SMILES: CN(C1CCN(CC(C)(F)F)CC1)c1ncc2nc(C)n(CC#Cc3ccc(Cl)cc3-c3ccnc4c(csc34)C(=O)NS(=O)(=O)C(F)(F)F)c(=O)c2c1C#N

InChI Key: InChIKey=BYANBKWBLVYGPV-UHFFFAOYSA-N

Data: 1 IC50

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Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 546104   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM546104
PNG
(US11286268, Compound 1603)
Show SMILES CN(C1CCN(CC(C)(F)F)CC1)c1ncc2nc(C)n(CC#Cc3ccc(Cl)cc3-c3ccnc4c(csc34)C(=O)NS(=O)(=O)C(F)(F)F)c(=O)c2c1C#N
Show InChI InChI=1S/C36H30ClF5N8O4S2/c1-20-46-28-17-45-32(48(3)23-9-13-49(14-10-23)19-35(2,38)39)26(16-43)29(28)34(52)50(20)12-4-5-21-6-7-22(37)15-25(21)24-8-11-44-30-27(18-55-31(24)30)33(51)47-56(53,54)36(40,41)42/h6-8,11,15,17-18,23H,9-10,12-14,19H2,1-3H3,(H,47,51)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 2.12n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair