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BDBM546106 US11286268, Compound 1605

SMILES: CN(C1CCN(CC(C)(F)F)CC1)c1ncc2nc(C)n(CC#Cc3ccc(Cl)cc3-c3ccnc4c(csc34)C(=O)NS(=O)(=O)C(C)(C)C)c(=O)c2c1C#N

InChI Key: InChIKey=WYAALRGMSGIFBQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 546106   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM546106
PNG
(US11286268, Compound 1605)
Show SMILES CN(C1CCN(CC(C)(F)F)CC1)c1ncc2nc(C)n(CC#Cc3ccc(Cl)cc3-c3ccnc4c(csc34)C(=O)NS(=O)(=O)C(C)(C)C)c(=O)c2c1C#N
Show InChI InChI=1S/C39H39ClF2N8O4S2/c1-23-46-31-20-45-35(48(6)26-12-16-49(17-13-26)22-39(5,41)42)29(19-43)32(31)37(52)50(23)15-7-8-24-9-10-25(40)18-28(24)27-11-14-44-33-30(21-55-34(27)33)36(51)47-56(53,54)38(2,3)4/h9-11,14,18,20-21,26H,12-13,15-17,22H2,1-6H3,(H,47,51)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 3.78n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair