BDBM548530 WO2022093881, Ex-10.39

SMILES C[C@]1(COC[C@@H]1F)N1CCN(CC1)c1cc2cc(NC(=O)[C@H]3C[C@@H](C3)C#N)ncc2cc1Cl

InChI Key InChIKey=YCFSGOJKZRVFCJ-IEVDNDAKSA-N

Data  1 IC50

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 548530   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
MERCK SHARP & DOHME LLC

WIPO
LigandPNGBDBM548530(WO2022093881, Ex-10.39)
Show SMILES C[C@]1(COC[C@@H]1F)N1CCN(CC1)c1cc2cc(NC(=O)[C@H]3C[C@@H](C3)C#N)ncc2cc1Cl
Show InChI InChI=1S/C24H27ClFN5O2/c1-24(14-33-13-21(24)26)31-4-2-30(3-5-31)20-9-16-10-22(28-12-18(16)8-19(20)25)29-23(32)17-6-15(7-17)11-27/h8-10,12,15,17,21H,2-7,13-14H2,1H3,(H,28,29,32)/t15-,17-,21-,24+/m0/s1
Affinity DataIC50: 0.0800nMAssay Description: The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen™ technology from Life Technologies Corporation (Carlsbad, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed