BDBM548547 WO2022093881, Ex-10.56

SMILES C[C@@H]1[C@@H]([C@H]1c1ccn(C)n1)C(=O)Nc1cc2cc(N3CCN(CC3)[C@@]3(C)COC[C@H]3O)c(Cl)cc2cn1

InChI Key InChIKey=NFQZZQDXCCTAFZ-CSUOMJFWSA-N

Data  1 IC50

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 548547   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
MERCK SHARP & DOHME LLC

WIPO
LigandPNGBDBM548547(WO2022093881, Ex-10.56)
Show SMILES C[C@@H]1[C@@H]([C@H]1c1ccn(C)n1)C(=O)Nc1cc2cc(N3CCN(CC3)[C@@]3(C)COC[C@H]3O)c(Cl)cc2cn1
Show InChI InChI=1S/C27H33ClN6O3/c1-16-24(20-4-5-32(3)31-20)25(16)26(36)30-23-12-17-11-21(19(28)10-18(17)13-29-23)33-6-8-34(9-7-33)27(2)15-37-14-22(27)35/h4-5,10-13,16,22,24-25,35H,6-9,14-15H2,1-3H3,(H,29,30,36)/t16-,22+,24+,25-,27-/m0/s1
Affinity DataIC50: 0.0800nMAssay Description: The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen™ technology from Life Technologies Corporation (Carlsbad, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed