BDBM548550 WO2022093881, Ex-10.59

SMILES Cc1cc2cnc(NC(=O)[C@@H]3C[C@H]3c3ccn(C)n3)cc2cc1N1CCN(CC1)[C@]1(C)COC[C@@H]1F

InChI Key InChIKey=YOXUCQBWQHCLLI-VAMBPCRVSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 548550   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
MERCK SHARP & DOHME LLC

WIPO
LigandPNGBDBM548550(WO2022093881, Ex-10.59)
Show SMILES Cc1cc2cnc(NC(=O)[C@@H]3C[C@H]3c3ccn(C)n3)cc2cc1N1CCN(CC1)[C@]1(C)COC[C@@H]1F
Show InChI InChI=1S/C27H33FN6O2/c1-17-10-19-14-29-25(30-26(35)21-13-20(21)22-4-5-32(3)31-22)12-18(19)11-23(17)33-6-8-34(9-7-33)27(2)16-36-15-24(27)28/h4-5,10-12,14,20-21,24H,6-9,13,15-16H2,1-3H3,(H,29,30,35)/t20-,21-,24+,27-/m1/s1
Affinity DataIC50: 0.0800nMAssay Description: The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen™ technology from Life Technologies Corporation (Carlsbad, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed