BDBM548565 WO2022093881, Ex-10.74

SMILES Cc1cc2cnc(NC(=O)[C@@H]3CC33CC3)cc2cc1N1CCN(CC1)[C@@]1(C)COC[C@H]1F

InChI Key InChIKey=JAUKWOJTFYLJGU-LEEZEASISA-N

Data  1 IC50

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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 548565   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
MERCK SHARP & DOHME LLC

WIPO
LigandPNGBDBM548565(WO2022093881, Ex-10.74)
Show SMILES Cc1cc2cnc(NC(=O)[C@@H]3CC33CC3)cc2cc1N1CCN(CC1)[C@@]1(C)COC[C@H]1F
Show InChI InChI=1S/C25H31FN4O2/c1-16-9-18-13-27-22(28-23(31)19-12-25(19)3-4-25)11-17(18)10-20(16)29-5-7-30(8-6-29)24(2)15-32-14-21(24)26/h9-11,13,19,21H,3-8,12,14-15H2,1-2H3,(H,27,28,31)/t19-,21+,24-/m0/s1
Affinity DataIC50: 0.0800nMAssay Description: The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen™ technology from Life Technologies Corporation (Carlsbad, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed