BDBM548578 WO2022093881, Ex-10.87

SMILES C[C@]1(C[C@H]1C(=O)Nc1cc2cc(N3CCN(CC3)[C@@]3(C)COC[C@H]3O)c(Cl)cc2cn1)C1CCOC1

InChI Key InChIKey=QZAQFTCOOZXHMO-LRCPNJLGSA-N

Data  1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 548578   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
MERCK SHARP & DOHME LLC

WIPO
LigandPNGBDBM548578(WO2022093881, Ex-10.87)
Show SMILES C[C@]1(C[C@H]1C(=O)Nc1cc2cc(N3CCN(CC3)[C@@]3(C)COC[C@H]3O)c(Cl)cc2cn1)C1CCOC1
Show InChI InChI=1S/C27H35ClN4O4/c1-26(19-3-8-35-14-19)12-20(26)25(34)30-24-11-17-10-22(21(28)9-18(17)13-29-24)31-4-6-32(7-5-31)27(2)16-36-15-23(27)33/h9-11,13,19-20,23,33H,3-8,12,14-16H2,1-2H3,(H,29,30,34)/t19?,20-,23+,26-,27-/m0/s1
Affinity DataIC50: 0.0800nMAssay Description: The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen™ technology from Life Technologies Corporation (Carlsbad, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed