BDBM548602 WO2022093881, Ex-17.1

SMILES Cn1ncc(n1)C1CC1C(=O)Nc1cc2cc(N3CCN(CC3)[C@]3(C)COC[C@]3(C)O)c(Cl)cc2cn1

InChI Key InChIKey=OJIUPXQWUAETON-GTDXGSHGSA-N

Data  1 IC50

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 548602   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
MERCK SHARP & DOHME LLC

WIPO
LigandPNGBDBM548602(WO2022093881, Ex-17.1)
Show SMILES Cn1ncc(n1)C1CC1C(=O)Nc1cc2cc(N3CCN(CC3)[C@]3(C)COC[C@]3(C)O)c(Cl)cc2cn1
Show InChI InChI=1S/C26H32ClN7O3/c1-25(14-37-15-26(25,2)36)34-6-4-33(5-7-34)22-9-16-10-23(28-12-17(16)8-20(22)27)30-24(35)19-11-18(19)21-13-29-32(3)31-21/h8-10,12-13,18-19,36H,4-7,11,14-15H2,1-3H3,(H,28,30,35)/t18?,19?,25-,26+/m1/s1
Affinity DataIC50: 0.0800nMAssay Description: The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen™ technology from Life Technologies Corporation (Carlsbad, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed