BDBM548846 WO2022098806, Compound 2-107::WO2022098806, Compound 2-184::WO2022098806, Compound 2-185

SMILES CN1CCc2cc(F)c(Nc3ncc4c(N)c(F)c(c(Cl)c4n3)-c3cnc4OCCNc4c3C)cc2C1

InChI Key InChIKey=AKFOSIZLCQSOSQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 548846   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck Sharp &Amp

WIPO
LigandPNGBDBM548846(WO2022098806, Compound 2-107 | WO2022098806, Compo...)
Affinity DataIC50:  0.0900nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck Sharp &Amp

WIPO
LigandPNGBDBM548846(WO2022098806, Compound 2-107 | WO2022098806, Compo...)
Affinity DataIC50:  0.0300nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Merck Sharp &Amp

WIPO
LigandPNGBDBM548846(WO2022098806, Compound 2-107 | WO2022098806, Compo...)
Affinity DataIC50:  3.67nMAssay Description: To each well of black Corning #3820384-well plate, an ECHO was used to dispense 7.5 nL of DMSO or Test compound in DMSO. A 1.5x kinase solution, 5 &...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed