BDBM5775 4-butoxy-5-[(2,4,6-trifluorophenyl)carbonyl]-1H-pyrazolo[3,4-b]pyridine::SQ-67563 Analog 21g::pyrazolo[3,4-b]pyridine deriv.

SMILES CCCCOc1c(cnc2[nH]ncc12)C(=O)c1c(F)cc(F)cc1F

InChI Key InChIKey=HEFHQIBQGOCQAF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 5775   

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM5775(4-butoxy-5-[(2,4,6-trifluorophenyl)carbonyl]-1H-py...)
Affinity DataIC50:  92nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM5775(4-butoxy-5-[(2,4,6-trifluorophenyl)carbonyl]-1H-py...)
Affinity DataIC50:  36nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM5775(4-butoxy-5-[(2,4,6-trifluorophenyl)carbonyl]-1H-py...)
Affinity DataIC50:  50nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM5775(4-butoxy-5-[(2,4,6-trifluorophenyl)carbonyl]-1H-py...)
Affinity DataIC50:  20nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM5775(4-butoxy-5-[(2,4,6-trifluorophenyl)carbonyl]-1H-py...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM5775(4-butoxy-5-[(2,4,6-trifluorophenyl)carbonyl]-1H-py...)
Affinity DataIC50:  690nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed