BDBM6219 BMCL182776 Compound 1::Chlorobenzodioxole deriv. 28::N-(5-chloro-2H-1,3-benzodioxol-4-yl)-6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-amine

SMILES COc1cc2c(Nc3c4OCOc4ccc3Cl)ncnc2cc1OCCCN1CCCCC1

InChI Key InChIKey=QHIMVPIOWKYPSO-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 6219   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM6219(BMCL182776 Compound 1 | Chlorobenzodioxole deriv. ...)
Affinity DataIC50:  2.17E+4nMAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit receptor tyrosine kinase activity. The compounds were incubated with enzym...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM6219(BMCL182776 Compound 1 | Chlorobenzodioxole deriv. ...)
Affinity DataIC50: <4nMT: 2°CAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM6219(BMCL182776 Compound 1 | Chlorobenzodioxole deriv. ...)
Affinity DataIC50: >1.00E+5nMAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit receptor tyrosine kinase activity. The compounds were incubated with enzym...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM6219(BMCL182776 Compound 1 | Chlorobenzodioxole deriv. ...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human c-SRC expressed in mouse NIH/3T3 cells assessed as reduction in BrdU incorporation after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM6219(BMCL182776 Compound 1 | Chlorobenzodioxole deriv. ...)
Affinity DataIC50:  350nMpH: 7.4 T: 2°CAssay Description:This assay detects inhibitors of EphB4-mediated phosphorylation of a polypeptide substrate using Alphascreen luminescence detection technology. The r...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM6219(BMCL182776 Compound 1 | Chlorobenzodioxole deriv. ...)
Affinity DataIC50: <4nMAssay Description:Inhibition of human recombinant pp60c-src expressed in baculovirus infected Sf9 insect cells using poly(Glu,Tyr) 4:1 as substrate after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM6219(BMCL182776 Compound 1 | Chlorobenzodioxole deriv. ...)
Affinity DataIC50: >1.00E+5nMAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit receptor tyrosine kinase activity. The compounds were incubated with enzym...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed