BDBM64871 N-(6-chloranylpyridin-3-yl)-4-fluoranyl-benzamide::N-(6-chloro-3-pyridinyl)-4-fluorobenzamide::N-(6-chloro-3-pyridyl)-4-fluoro-benzamide::N-(6-chloropyridin-3-yl)-4-fluorobenzamide::US11365181, Compound ZTZ240::ZTZ240::cid_3780776

SMILES Fc1ccc(cc1)C(=O)Nc1ccc(Cl)nc1

InChI Key InChIKey=URPKVELJRWKNQS-UHFFFAOYSA-N

Data  1 IC50  1 Kd  4 EC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 64871   

TargetPotassium voltage-gated channel subfamily KQT member 2(Rattus norvegicus)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM64871(N-(6-chloranylpyridin-3-yl)-4-fluoranyl-benzamide ...)
Affinity DataEC50:  5.80E+3nMAssay Description:Data Source: Johns Hopkins Ion Channel Center BioAssay Type: Mode of Action, Electrophysiology Source (MLPCN Center Name): Johns Hopkins Ion Channel...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Rattus norvegicus)
Johns Hopkins Ion Channel Center

Curated by PubChem BioAssay
LigandPNGBDBM64871(N-(6-chloranylpyridin-3-yl)-4-fluoranyl-benzamide ...)
Affinity DataEC50:  5.90E+3nMAssay Description:Data Source: Johns Hopkins Ion Channel Center BioAssay Type: Mode of Action, Electrophysiology Source (MLPCN Center Name): Johns Hopkins Ion Channel...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2(Homo sapiens (Human))
Shanghai Zhimeng Biopharma

US Patent
LigandPNGBDBM64871(N-(6-chloranylpyridin-3-yl)-4-fluoranyl-benzamide ...)
Affinity DataEC50:  8.23E+3nMAssay Description:Cell preparation: CHO-KCNQ2 cells were cultured in a 175 cm2 culture flask, and when the cells was grown to a density of 60-80%, the culture medium w...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM64871(N-(6-chloranylpyridin-3-yl)-4-fluoranyl-benzamide ...)
Affinity DataEC50:  980nMAssay Description:Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM64871(N-(6-chloranylpyridin-3-yl)-4-fluoranyl-benzamide ...)
Affinity DataIC50:  6.60E+4nMAssay Description:Antagonist activity at KCNQ1/MINK expressed in CHO cells assessed as inhibition of KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induct...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM64871(N-(6-chloranylpyridin-3-yl)-4-fluoranyl-benzamide ...)
Affinity DataKd:  1.14E+5nMAssay Description:Binding affinity to BACE1 (unknown origin) by surface plasmon resonance spectroscopic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed