BDBM6571 N-[2-(4-{[6-(2,6-dichlorophenyl)-8-methyl-7-oxo-7H,8H-pyrido[2,3-d]pyrimidin-2-yl]amino}phenoxy)ethyl]-N-ethylacetamide::PD179483

SMILES CCN(CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1)C(C)=O

InChI Key InChIKey=ZPDSBOKGPBKXNQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 6571   

TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6571(N-[2-(4-{[6-(2,6-dichlorophenyl)-8-methyl-7-oxo-7H...)
Affinity DataIC50:  9.03nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6571(N-[2-(4-{[6-(2,6-dichlorophenyl)-8-methyl-7-oxo-7H...)
Affinity DataIC50: <5nMAssay Description:The kinase activity was measured by DELFIA/time-resolved fluorometry. The reaction was carried out in 96-well polypropylene plates and was terminated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6571(N-[2-(4-{[6-(2,6-dichlorophenyl)-8-methyl-7-oxo-7H...)
Affinity DataIC50:  463nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6571(N-[2-(4-{[6-(2,6-dichlorophenyl)-8-methyl-7-oxo-7H...)
Affinity DataIC50:  244nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed