BDBM6760 (+)-K-252a::CHEMBL281948::K-252a::methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaene-16-carboxylate

SMILES COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13

InChI Key InChIKey=KOZFSFOOLUUIGY-BEJFKGIZSA-N

Data  1 KI  20 IC50

PDB links: 5 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 6760   

TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society

Curated by ChEMBL
LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataKi:  20nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  530nMAssay Description:Inhibition of PKCtheta (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Cephalon

LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  22nMpH: 7.2 T: 2°CAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Cephalon

LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  13nMAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 10(Homo sapiens (Human))
Cephalon

LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  45nMAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  150nMpH: 7.6 T: 2°CAssay Description:A coupled-enzyme assay was used to quantify the ADP generated in the kinase reaction with S6 peptide (RRRLSSLRA) as the phosphoacceptorsubstrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  43nMAssay Description:Inhibition of VEGF-receptor 2 (KDR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  13nMAssay Description:Inhibition of nerve growth factor receptor, trkAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society

Curated by ChEMBL
LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  22nMAssay Description:Inhibition of Myosin light chain kinase 1 (MLCK1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Kyowa Hakko Kogyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of Smooth muscle myosin light chain kinase of chicken gizzardMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  2.40nMAssay Description:Ability to inhibit human trk A tyrosine kinase expressed in baculovirus using ELISA based enzyme assay was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase(Oryctolagus cuniculus (Rabbit))
Kyowa Hakko Kogyo Co., Ltd

Curated by ChEMBL
LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  0.0160nMAssay Description:Inhibition of cAMP dependent Protein kinase A of rabbit Skeletal Muscle.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  13nMAssay Description:Inhibition of baculovirus expressed human trkAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  60nMAssay Description:Inhibition of protein kinase C (PKC) isozymeMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein kinase C zeta type(Rattus norvegicus)TBA
LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibition of protein kinase C from rat brain.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein kinase C zeta type(Rattus norvegicus)TBA
LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  250nMAssay Description:Inhibition of protein kinase CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Eli Lilly and Company

LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  30nMpH: 7.0 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Eli Lilly and Company

LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  260nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed