BDBM6867 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3c::4-({5-amino-1-[(2,6-difluoro-3-methylphenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzene-1-sulfonamide::4-[[5-Amino-1-(2,6-difluoro-3-methylbenzoyl)-1H-1,2,4-triazol-3-yl]amino]-benzenesulfonamide

SMILES Cc1ccc(F)c(C(=O)n2nc(Nc3ccc(cc3)S(N)(=O)=O)nc2N)c1F

InChI Key InChIKey=IEWLQUDDCQIINQ-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 6867   

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6867(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3c ...)
Affinity DataIC50:  8nMpH: 8.0 T: 2°CAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6867(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3c ...)
Affinity DataIC50:  0.300nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Mus musculus (mouse))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6867(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3c ...)
Affinity DataIC50:  190nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6867(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3c ...)
Affinity DataIC50: >1.00E+5nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6867(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3c ...)
Affinity DataIC50:  510nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6867(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3c ...)
Affinity DataIC50:  4.58E+4nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6867(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3c ...)
Affinity DataIC50: >1.00E+5nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6867(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3c ...)
Affinity DataIC50:  1.07E+4nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta [7-25](Oryctolagus cuniculus (rabbit))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6867(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3c ...)
Affinity DataIC50:  31nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6867(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3c ...)
Affinity DataIC50:  9.80E+3nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform delta(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6867(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3c ...)
Affinity DataIC50: >1.00E+5nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6867(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3c ...)
Affinity DataIC50:  9.50E+3nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6867(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3c ...)
Affinity DataIC50:  270nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 10 uM ATP/[gamma-33P]ATP in a streptavidin coated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed