BDBM7007 Indenopyrazole deriv. 6::N-[3-(4-methoxyphenyl)-4-oxo-2H,4H-indeno[1,2-c]pyrazol-5-yl]-2-methylpropanamide

SMILES COc1ccc(cc1)-c1[nH]nc2-c3cccc(NC(=O)C(C)C)c3C(=O)c12

InChI Key InChIKey=JKYJMEJOTVNJIB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 7007   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Dupont Pharmaceuticals

LigandPNGBDBM7007(Indenopyrazole deriv. 6 | N-[3-(4-methoxyphenyl)-4...)
Affinity DataIC50:  3.50E+4nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM7007(Indenopyrazole deriv. 6 | N-[3-(4-methoxyphenyl)-4...)
Affinity DataIC50:  1.41E+3nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM7007(Indenopyrazole deriv. 6 | N-[3-(4-methoxyphenyl)-4...)
Affinity DataIC50:  1.40E+3nMpH: 7.6 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed