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BDBM71097 US9546164, 233::US9694002, 233

SMILES: Fc1cc(OCC2CCN(CC2)C(=O)c2ccc(Cl)c(Cl)c2)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1

InChI Key: InChIKey=RUJWRSKJYRGFJT-UHFFFAOYSA-N

Data: 2 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 71097   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM71097
PNG
(US9546164, 233 | US9694002, 233)
Show SMILES Fc1cc(OCC2CCN(CC2)C(=O)c2ccc(Cl)c(Cl)c2)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C26H27Cl2FN2O5S/c27-21-6-3-17(11-22(21)28)26(33)31-9-7-15(8-10-31)14-36-24-13-23(29)20(12-19(24)16-1-2-16)25(32)30-37(34,35)18-4-5-18/h3,6,11-13,15-16,18H,1-2,4-5,7-10,14H2,(H,30,32)
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PC cid
PC sid
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Similars

US Patent
n/an/a 31n/an/an/an/a7.425



Genentech Inc

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...


US Patent US9546164 (2017)


BindingDB Entry DOI: 10.7270/Q2JD4ZS4
More data for this
Ligand-Target Pair
Sodium Channel Complex


(Homo sapiens (Human))
BDBM71097
PNG
(US9546164, 233 | US9694002, 233)
Show SMILES Fc1cc(OCC2CCN(CC2)C(=O)c2ccc(Cl)c(Cl)c2)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C26H27Cl2FN2O5S/c27-21-6-3-17(11-22(21)28)26(33)31-9-7-15(8-10-31)14-36-24-13-23(29)20(12-19(24)16-1-2-16)25(32)30-37(34,35)18-4-5-18/h3,6,11-13,15-16,18H,1-2,4-5,7-10,14H2,(H,30,32)
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 31n/an/an/an/a7.425



Genentech Inc

US Patent


Assay Description
Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...


US Patent US9694002 (2017)


BindingDB Entry DOI: 10.7270/Q24B2ZFG
More data for this
Ligand-Target Pair