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BDBM71295 US9546164, 368::US9694002, 368

SMILES: CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(CC2)S(=O)(=O)c2ccc(Br)c(F)c2)cc1F

InChI Key: InChIKey=KNWMNXSIMFAJLJ-UHFFFAOYSA-N

Data: 2 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 71295   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM71295
PNG
(US9546164, 368 | US9694002, 368)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(CC2)S(=O)(=O)c2ccc(Br)c(F)c2)cc1F
Show InChI InChI=1S/C23H25BrF2N2O6S2/c1-35(30,31)27-23(29)18-11-17(15-2-3-15)22(12-20(18)25)34-13-14-6-8-28(9-7-14)36(32,33)16-4-5-19(24)21(26)10-16/h4-5,10-12,14-15H,2-3,6-9,13H2,1H3,(H,27,29)
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PC cid
PC sid
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Similars

US Patent
n/an/a 25.1n/an/an/an/a7.425



Genentech Inc

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...


US Patent US9546164 (2017)


BindingDB Entry DOI: 10.7270/Q2JD4ZS4
More data for this
Ligand-Target Pair
Sodium Channel Complex


(Homo sapiens (Human))
BDBM71295
PNG
(US9546164, 368 | US9694002, 368)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(CC2)S(=O)(=O)c2ccc(Br)c(F)c2)cc1F
Show InChI InChI=1S/C23H25BrF2N2O6S2/c1-35(30,31)27-23(29)18-11-17(15-2-3-15)22(12-20(18)25)34-13-14-6-8-28(9-7-14)36(32,33)16-4-5-19(24)21(26)10-16/h4-5,10-12,14-15H,2-3,6-9,13H2,1H3,(H,27,29)
PDB

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UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 25n/an/an/an/a7.425



Genentech Inc

US Patent


Assay Description
Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...


US Patent US9694002 (2017)


BindingDB Entry DOI: 10.7270/Q24B2ZFG
More data for this
Ligand-Target Pair