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BDBM71302 US9546164, 374::US9694002, 374

SMILES: CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(CC2)S(=O)(=O)c2cccc(c2)C(F)(F)F)cc1F

InChI Key: InChIKey=HFUQIJGZENHTPZ-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 71302   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM71302
PNG
(US9546164, 374 | US9694002, 374)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(CC2)S(=O)(=O)c2cccc(c2)C(F)(F)F)cc1F
Show InChI InChI=1S/C24H26F4N2O6S2/c1-37(32,33)29-23(31)20-12-19(16-5-6-16)22(13-21(20)25)36-14-15-7-9-30(10-8-15)38(34,35)18-4-2-3-17(11-18)24(26,27)28/h2-4,11-13,15-16H,5-10,14H2,1H3,(H,29,31)
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PC cid
PC sid
UniChem
US Patent
n/an/a 23.1n/an/an/an/a7.425



Genentech Inc

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...


US Patent US9546164 (2017)


BindingDB Entry DOI: 10.7270/Q2JD4ZS4
More data for this
Ligand-Target Pair
Sodium Channel Complex


(Homo sapiens (Human))
BDBM71302
PNG
(US9546164, 374 | US9694002, 374)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(CC2)S(=O)(=O)c2cccc(c2)C(F)(F)F)cc1F
Show InChI InChI=1S/C24H26F4N2O6S2/c1-37(32,33)29-23(31)20-12-19(16-5-6-16)22(13-21(20)25)36-14-15-7-9-30(10-8-15)38(34,35)18-4-2-3-17(11-18)24(26,27)28/h2-4,11-13,15-16H,5-10,14H2,1H3,(H,29,31)
PDB

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UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 23n/an/an/an/a7.425



Genentech Inc

US Patent


Assay Description
Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...


US Patent US9694002 (2017)


BindingDB Entry DOI: 10.7270/Q24B2ZFG
More data for this
Ligand-Target Pair