BDBM7279 2-(3-hydroxy-1-propinyl)-9-trifluoromethylpaullone::4-(3-hydroxyprop-1-yn-1-yl)-14-(trifluoromethyl)-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octadeca-1(11),2,4,6,12(17),13,15-heptaen-9-one::CHEMBL346406::NSC 708247::Paullone Analog 18

SMILES OCC#Cc1ccc2NC(=O)Cc3c([nH]c4ccc(cc34)C(F)(F)F)-c2c1

InChI Key InChIKey=QNQUCAXGTRFYJH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 7279   

TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Cnrs

LigandPNGBDBM7279(2-(3-hydroxy-1-propinyl)-9-trifluoromethylpaullone...)
Affinity DataIC50:  300nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7279(2-(3-hydroxy-1-propinyl)-9-trifluoromethylpaullone...)
Affinity DataIC50:  300nMAssay Description:Inhibition of Cyclin-dependent kinase 1-cyclin B from Starfish oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Cnrs

LigandPNGBDBM7279(2-(3-hydroxy-1-propinyl)-9-trifluoromethylpaullone...)
Affinity DataIC50:  200nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Cnrs

LigandPNGBDBM7279(2-(3-hydroxy-1-propinyl)-9-trifluoromethylpaullone...)
Affinity DataIC50:  2.00E+3nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed