BDBM7295 (E)-2-(3-oxo-1-butenyl)-9-trifluoromethylpaullone::4-[(1E)-3-oxobut-1-en-1-yl]-14-(trifluoromethyl)-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octadeca-1(11),2,4,6,12(17),13,15-heptaen-9-one::CHEMBL119989::Paullone Analog 34

SMILES CC(=O)C=Cc1ccc2NC(=O)Cc3c([nH]c4ccc(cc34)C(F)(F)F)-c2c1

InChI Key InChIKey=LTULTOYPFRYCKS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 7295   

TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Cnrs

LigandPNGBDBM7295((E)-2-(3-oxo-1-butenyl)-9-trifluoromethylpaullone ...)
Affinity DataIC50:  320nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM7295((E)-2-(3-oxo-1-butenyl)-9-trifluoromethylpaullone ...)
Affinity DataIC50:  320nMAssay Description:Inhibition of Cyclin-dependent kinase 1-cyclin B from Starfish oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Cnrs

LigandPNGBDBM7295((E)-2-(3-oxo-1-butenyl)-9-trifluoromethylpaullone ...)
Affinity DataIC50:  1.40E+3nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Cnrs

LigandPNGBDBM7295((E)-2-(3-oxo-1-butenyl)-9-trifluoromethylpaullone ...)
Affinity DataIC50:  3.40E+4nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed