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BDBM74633 6-(2,6-dimethyl-4-morpholinyl)-3-(2-methylphenyl)-1H-pyrimidine-2,4-dione::6-(2,6-dimethylmorpholin-4-yl)-3-(2-methylphenyl)-1H-pyrimidine-2,4-dione::6-(2,6-dimethylmorpholin-4-yl)-3-(2-methylphenyl)pyrimidine-2,4(1H,3H)-dione::6-(2,6-dimethylmorpholino)-3-(o-tolyl)uracil::MLS000045903::SMR000028280::cid_3241172

SMILES: CC1CN(CC(C)O1)c1cc(=O)n(-c2ccccc2C)c(=O)[nH]1

InChI Key: InChIKey=GAKBJPUAVSVXHC-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 74633   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens (Human))
BDBM74633
PNG
(6-(2,6-dimethyl-4-morpholinyl)-3-(2-methylphenyl)-...)
Show SMILES CC1CN(CC(C)O1)c1cc(=O)n(-c2ccccc2C)c(=O)[nH]1
Show InChI InChI=1S/C17H21N3O3/c1-11-6-4-5-7-14(11)20-16(21)8-15(18-17(20)22)19-9-12(2)23-13(3)10-19/h4-8,12-13H,9-10H2,1-3H3,(H,18,22)
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MMDB

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PC sid
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Similars

PCBioAssay
n/an/an/an/a>5.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


PubChem Bioassay (2010)


BindingDB Entry DOI: 10.7270/Q280513R
More data for this
Ligand-Target Pair