BDBM7840 RIVAROXABAN::US8822458, 44::US8822458, 97
SMILES Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O
InChI Key InChIKey=KGFYHTZWPPHNLQ-AWEZNQCLSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 26 hits for monomerid = 7840
Affinity DataKi: 0.400nMAssay Description:Inhibition of Factor 10a (unknown origin)More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 0.400nMAssay Description:Inhibition of human factor 10a using pefachrome F10a as substrate preincubated for 10 mins followed by substrate addition and measured for 20 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Inhibition of factor-10a (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.660nMAssay Description:Inhibition of F10a (unknown origin) using S-2222 as substrate incubated for 15 mins prior to substrate addition measured every 10 secs by spectrophot...More data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Inhibition of human activated Factor X using S-2765 as substrate incubated for 15 mins followed by substrate addition and measured after 1 hr by chro...More data for this Ligand-Target Pair
TargetSuppressor of tumorigenicity 14 protein(Homo sapiens (Human))
Washington University
Curated by ChEMBL
Washington University
Curated by ChEMBL
Affinity DataKi: 3.35E+3nMAssay Description:Inhibition of matripase (unknown origin) using Boc-QAR-AMC as substrate incubated for 30 mins prior to substrate addition by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human F10a using S-2765 as substrate after 45 mins by spectra max analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of F10a in human plasma assessed as doubling of prothombin timeMore data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibition of F10a in human plasma assessed as doubling of activated partial thromboplastin timeMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of human F10a using S-2765 as substrate preincubated for 10 mins followed by substrate addition by microplate reader analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of factor 10aMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human F10a using S-2765 as substrate after 45 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human coagulation factor Xa using Boc-Ile-Glu-Gly-Arg-AMC as fluorogenic substrate measured at 1 min interval for 1 hr by fluorometric ...More data for this Ligand-Target Pair
TargetCoagulation factor X(Oryctolagus cuniculus)
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 860nMAssay Description:Inhibition of F10a in rabbit plasma assessed as doubling of activated partial thromboplastin timeMore data for this Ligand-Target Pair
TargetCoagulation factor X(Oryctolagus cuniculus)
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 510nMAssay Description:Inhibition of F10a in rabbit plasma assessed as doubling of prothombin timeMore data for this Ligand-Target Pair
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human factor 10a using N-Z-D-Arg-Gly-Arg-pNA, S-2765 chromogenic substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMpH: 8.3 T: 2°CAssay Description:The enzymatic activity was measured using chromogenic or fluorogenic substrates in 96-well microtiter plates.Color change was monitored continuously ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMT: 2°CAssay Description:The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...More data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human coagulation factor XIIA using Boc-Gln-Gly-Arg-AMC as fluorogenic substrate measured at 1 min interval for 1 hr by fluorometric as...More data for this Ligand-Target Pair
Affinity DataIC50: 4.59nMAssay Description:Inhibition of human factor 10a assessed as CBS 31.39 substrate hydrolysis by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 700nMT: 2°CAssay Description:The enzymatic activity of human factor Xa (FXa) was measured using the conversion of a chromogenic substrate specific for FXa. Factor Xa cleaves p-ni...More data for this Ligand-Target Pair