BDBM838 Benzocycloalkyl Amines deriv. 8::tert-butyl N-[(2S,3S,5R)-5-benzyl-3-hydroxy-5-{[(1S,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]carbamoyl}-1-phenylpentan-2-yl]carbamate

SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H]1[C@@H](O)Cc2ccccc12

InChI Key InChIKey=ZJBUCZFZQXPYFC-KMMGOQOWSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 838   

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of Missouri St. Louis

Curated by ChEMBL
LigandPNGBDBM838(Benzocycloalkyl Amines deriv. 8 | tert-butyl N-[(2...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of human immunodeficiency virus type 1 (HIV-1) protease enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Sharp And Dohme Research Laboratories

LigandPNGBDBM838(Benzocycloalkyl Amines deriv. 8 | tert-butyl N-[(2...)
Affinity DataIC50:  259nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed