BDBM8466 (2R)-N-hydroxy-2-[(4-methoxybenzene)sulfonamido]-3-methylbutanamide::CHEMBL114272::hydroxamate analogue 2

SMILES COc1ccc(cc1)S(=O)(=O)N[C@H](C(C)C)C(=O)NO

InChI Key InChIKey=SUEBJDNLBVTIQP-LLVKDONJSA-N

Data  2 KI  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 8466   

Target72 kDa type IV collagenase(Homo sapiens (Human))
Pomona College

Curated by ChEMBL
LigandPNGBDBM8466((2R)-N-hydroxy-2-[(4-methoxybenzene)sulfonamido]-3...)
Affinity DataKi:  81nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pomona College

Curated by ChEMBL
LigandPNGBDBM8466((2R)-N-hydroxy-2-[(4-methoxybenzene)sulfonamido]-3...)
Affinity DataKi:  126nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM8466((2R)-N-hydroxy-2-[(4-methoxybenzene)sulfonamido]-3...)
Affinity DataIC50:  170nMAssay Description:Inhibitory activity against human matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM8466((2R)-N-hydroxy-2-[(4-methoxybenzene)sulfonamido]-3...)
Affinity DataIC50:  1.70nMAssay Description:Inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM8466((2R)-N-hydroxy-2-[(4-methoxybenzene)sulfonamido]-3...)
Affinity DataKd:  43nMAssay Description:Binding affinity to stromelysin-1 catalytic domain expressed in Escherichia coli BL21 (DE3) by isothermal titration colorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Duke University

Curated by ChEMBL
LigandPNGBDBM8466((2R)-N-hydroxy-2-[(4-methoxybenzene)sulfonamido]-3...)
Affinity DataKd:  113nMAssay Description:Binding affinity to stromelysin-1 catalytic domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Merck Research Laboratories

LigandPNGBDBM8466((2R)-N-hydroxy-2-[(4-methoxybenzene)sulfonamido]-3...)
Affinity DataIC50:  900nMpH: 7.0 T: 2°CAssay Description:The assay was performed in a 96-well plate, each well contained substrate peptide, LF, and the test compound. The C-terminally fluorophore of substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed