BDBM8494 (2R)-2-[(4-fluoro-3-methylbenzene)sulfonamido]-N-hydroxypropanamide::hydroxamate analogue 31

SMILES C[C@@H](NS(=O)(=O)c1ccc(F)c(C)c1)C(=O)NO

InChI Key InChIKey=PGNDHTMCXOFNMS-SSDOTTSWSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 8494   

TargetLethal factor(Bacillus anthracis)
Merck Research Laboratories

LigandPNGBDBM8494((2R)-2-[(4-fluoro-3-methylbenzene)sulfonamido]-N-h...)
Affinity DataIC50:  130nMAssay Description:The assay was performed in a 96-well plate, each well contained substrate peptide, LF, and the test compound. The C-terminally fluorophore of substra...More data for this Ligand-Target Pair
TargetLethal factor(Bacillus anthracis)
Merck Research Laboratories

LigandPNGBDBM8494((2R)-2-[(4-fluoro-3-methylbenzene)sulfonamido]-N-h...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of Bacillus anthracis Lethal factor after 5 mins by FRET assayMore data for this Ligand-Target Pair
TargetLethal factor(Bacillus anthracis)
Merck Research Laboratories

LigandPNGBDBM8494((2R)-2-[(4-fluoro-3-methylbenzene)sulfonamido]-N-h...)
Affinity DataIC50:  500nMAssay Description:Inhibition of Bacillus anthracis Lethal factor after 10 mins by mobility shift protease assay using 8 uM FITC as substrateMore data for this Ligand-Target Pair