BDBM85619 1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl]urea::CHEMBL138332::MRE 3010F20

SMILES CCCn1cc2c(n1)nc(NC(=O)Nc1cccc(Cl)c1)n1nc(nc21)-c1ccco1

InChI Key InChIKey=NFDDKDIFVJEASK-UHFFFAOYSA-N

Data  21 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 85619   

TargetAdenosine receptor A3(Homo sapiens (Human))
University Of Ferrara

Curated by PDSP Ki Database
LigandPNGBDBM85619(1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-p...)
Affinity DataKi:  0.480nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
University Of Ferrara

Curated by PDSP Ki Database
LigandPNGBDBM85619(1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-p...)
Affinity DataKi:  0.490nMAssay Description:Displacement of [125]AB-MECA from human Adenosine A3 receptor expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
University Of Ferrara

Curated by PDSP Ki Database
LigandPNGBDBM85619(1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-p...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]-MRE3008-F20 from human adenosine A3 receptor expressed in CHO cells; range 0.85-0.98More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
University Of Ferrara

Curated by PDSP Ki Database
LigandPNGBDBM85619(1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-p...)
Affinity DataKi:  0.910nMAssay Description:Binding affinity to human adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A3(Homo sapiens (Human))
University Of Ferrara

Curated by PDSP Ki Database
LigandPNGBDBM85619(1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-p...)
Affinity DataKi:  0.910nMAssay Description:Antagonist activity at human adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
University Of Ferrara

Curated by PDSP Ki Database
LigandPNGBDBM85619(1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-p...)
Affinity DataKi:  0.910nMAssay Description:Displacement of [3H]NECA from human adenosine A3 receptor expressed in CHO cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
University Of Ferrara

Curated by PDSP Ki Database
LigandPNGBDBM85619(1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-p...)
Affinity DataKi:  0.910nMAssay Description:Binding affinity for human adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
University Of Ferrara

Curated by PDSP Ki Database
LigandPNGBDBM85619(1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-p...)
Affinity DataKi:  0.910nMAssay Description:Displacement of [3H]-MRE3008-F20 binding at human Adenosine A3 receptor expressed in HEK cells; range 0.85-0.98More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
University Of Ferrara

Curated by PDSP Ki Database
LigandPNGBDBM85619(1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-p...)
Affinity DataKi:  0.980nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM85619(1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-p...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]-DPCPX from human adenosine A1 receptor expressed in CHO cells; range 23-40More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM85619(1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-p...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]-DPCPX from human Adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM85619(1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-p...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]-DPCPX from human Adenosine A1 receptor expressed in CHO cells; range 23-40More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM85619(1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-p...)
Affinity DataKi:  57nMAssay Description:Displacement of [3H]-DPCPX from Adenosine A2b receptor expressed in CHO cells; range 50-63More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM85619(1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-p...)
Affinity DataKi:  57nMAssay Description:Displacement of [3H]-DPCPX from human Adenosine A2B receptor expressed in HEK-293 cells; range 50-63More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM85619(1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-p...)
Affinity DataKi:  1.22E+3nMAssay Description:Displacement of [3H]-SCH-58,261 from human Adenosine A2A receptor expressed in HEK-293 cells; range 880-1682More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM85619(1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-p...)
Affinity DataKi:  1.22E+3nMAssay Description:Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM85619(1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-p...)
Affinity DataKi:  1.22E+3nMAssay Description:Displacement of [3H]-SCH- 58261 from human adenosine A2A receptor expressed in CHO cells; range 880-1682More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM85619(1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-p...)
Affinity DataKi:  1.22E+3nMAssay Description:Displacement of [3H]-SCH- 58261 from human Adenosine A2A receptor expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM85619(1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-p...)
Affinity DataKi:  1.58E+3nMAssay Description:Displacement of [3H]-DPCPX from Adenosine A1 receptor of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
University Of Ferrara

Curated by PDSP Ki Database
LigandPNGBDBM85619(1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-p...)
Affinity DataKi:  1.58E+3nMAssay Description:Displacement of [3H]MRE3008-F20 from human adenosine A3 receptor expressed in CHO cells after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM85619(1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-p...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-SCH- 58261 from Adenosine A2A receptor in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
University Of Ferrara

Curated by PDSP Ki Database
LigandPNGBDBM85619(1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-p...)
Affinity DataIC50:  5.30nMAssay Description:Inhibitory concentration as antagonistic activity against cAMP generation inhibited by IB-MECA in CHO cell membranes transfected with human A3 recept...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
University Of Ferrara

Curated by PDSP Ki Database
LigandPNGBDBM85619(1-(3-chlorophenyl)-3-[2-(furan-2-yl)-8-propyl-8H-p...)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of cAMP accumulation in CHO cells expressing human adenosine A3 receptor; range 4.0-7.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed