BDBM883 L-685,434 deriv. 31::N-(2(R)-Hydroxy-1(S)-indanyl)-5(S)-[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-[4-[2-(4-morpholinyl)ethoxy]phenyl]-2-(R)-[[4-[2-(4-morphholinyl)ethoxy]phenyl]methyl]hexanamide::tert-butyl N-[(2S,3S,5R)-3-hydroxy-5-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]carbamoyl}-1-{4-[2-(morpholin-4-yl)ethoxy]phenyl}-5-({4-[2-(morpholin-4-yl)ethoxy]phenyl}methyl)pentan-2-yl]carbamate

SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccc(OCCN2CCOCC2)cc1)[C@@H](O)C[C@@H](Cc1ccc(OCCN2CCOCC2)cc1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12

InChI Key InChIKey=WGHYNTCTLVBFHI-HATTVXFNSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 883   

TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM883(L-685,434 deriv. 31 | N-(2(R)-Hydroxy-1(S)-indanyl...)
Affinity DataIC50:  1.90nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed