BindingDB logo
myBDB logout

BDBM9065 Donepezil-tacrine hybrid 10::N-[6-(6-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamino)-hexyl]-2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)acetamide::N-{6-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]hexyl}-2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)acetamide

SMILES: Clc1ccc2c(NCCCCCCNC(=O)CN3C(=O)c4ccccc4C3=O)c3CCCCc3nc2c1

InChI Key: InChIKey=JFPMDULIXYETHU-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 9065   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cholinesterases


(Homo sapiens (Human))
BDBM9065
PNG
(Donepezil-tacrine hybrid 10 | N-[6-(6-Chloro-1,2,3...)
Show SMILES Clc1ccc2c(NCCCCCCNC(=O)CN3C(=O)c4ccccc4C3=O)c3CCCCc3nc2c1
Show InChI InChI=1S/C29H31ClN4O3/c30-19-13-14-23-25(17-19)33-24-12-6-5-11-22(24)27(23)32-16-8-2-1-7-15-31-26(35)18-34-28(36)20-9-3-4-10-21(20)29(34)37/h3-4,9-10,13-14,17H,1-2,5-8,11-12,15-16,18H2,(H,31,35)(H,32,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 220n/an/an/an/an/an/a



Neuropharma



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...


Bioorg Med Chem 13: 6588-97 (2005)


Article DOI: 10.1016/j.bmc.2005.09.029
BindingDB Entry DOI: 10.7270/Q2G73BW9
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Bos taurus (bovine))
BDBM9065
PNG
(Donepezil-tacrine hybrid 10 | N-[6-(6-Chloro-1,2,3...)
Show SMILES Clc1ccc2c(NCCCCCCNC(=O)CN3C(=O)c4ccccc4C3=O)c3CCCCc3nc2c1
Show InChI InChI=1S/C29H31ClN4O3/c30-19-13-14-23-25(17-19)33-24-12-6-5-11-22(24)27(23)32-16-8-2-1-7-15-31-26(35)18-34-28(36)20-9-3-4-10-21(20)29(34)37/h3-4,9-10,13-14,17H,1-2,5-8,11-12,15-16,18H2,(H,31,35)(H,32,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 10n/an/an/an/a8.030



Neuropharma



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 405 nm were recorded for 10 min with...


Bioorg Med Chem 13: 6588-97 (2005)


Article DOI: 10.1016/j.bmc.2005.09.029
BindingDB Entry DOI: 10.7270/Q2G73BW9
More data for this
Ligand-Target Pair