BDBM92443 MMP Inhibitor, 3::Thiophene derivative, compound 36::US8691753, 97
SMILES NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CCc1ccc(cc1)-c1cc(cs1)-c1ccccc1
InChI Key InChIKey=MMIHYNVQXYWTFM-PKTZIBPZSA-N
Data 32 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 32 hits for monomerid = 92443
Affinity DataKi: 1.90nM ΔG°: -11.9kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
Affinity DataKi: 1.92nM ΔG°: -11.9kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
Affinity DataKi: 3.70nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
Affinity DataKi: 410nM ΔG°: -8.71kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
Affinity DataKi: 410nM ΔG°: -8.71kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
Affinity DataKi: 684nM ΔG°: -8.40kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
Affinity DataKi: 684nM ΔG°: -8.40kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
TargetStromelysin-2(Homo sapiens (Human))
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Commissariat A L'Energie Atomique Et Aux Energies Alternatives
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Affinity DataKi: 693nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
Affinity DataKi: 694nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
Affinity DataKi: 714nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
TargetStromelysin-2(Homo sapiens (Human))
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Commissariat A L'Energie Atomique Et Aux Energies Alternatives
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Affinity DataKi: 872nM ΔG°: -8.26kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
TargetStromelysin-2(Homo sapiens (Human))
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US Patent
Commissariat A L'Energie Atomique Et Aux Energies Alternatives
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Affinity DataKi: 872nM ΔG°: -8.26kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nM ΔG°: >-8.18kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nM ΔG°: >-8.18kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-14 [1-20,P8S](Homo sapiens (Human))
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Commissariat A L'Energie Atomique Et Aux Energies Alternatives
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Affinity DataKi: >1.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
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Commissariat A L'Energie Atomique Et Aux Energies Alternatives
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Affinity DataKi: >1.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nM ΔG°: >-8.18kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives
US Patent
Commissariat A L'Energie Atomique Et Aux Energies Alternatives
US Patent
Affinity DataKi: >1.00E+3nM ΔG°: >-8.18kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
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US Patent
Commissariat A L'Energie Atomique Et Aux Energies Alternatives
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Affinity DataKi: 1.06E+3nM ΔG°: -8.15kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
Affinity DataKi: 2.01E+3nM ΔG°: -7.77kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
Affinity DataKi: 3.01E+3nM ΔG°: -7.53kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
Affinity DataKi: 3.88E+3nM ΔG°: -7.38kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
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Commissariat A L'Energie Atomique Et Aux Energies Alternatives
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Affinity DataKi: >5.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
Affinity DataKi: >5.00E+3nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17 [215-477,S266A,N452Q](Homo sapiens (Human))
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Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
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US Patent
Commissariat A L'Energie Atomique Et Aux Energies Alternatives
US Patent
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Commissariat A L'Energie Atomique Et Aux Energies Alternatives
US Patent
Commissariat A L'Energie Atomique Et Aux Energies Alternatives
US Patent
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:The inhibition tests and the evaluation of the inhibition constants (Ki) on the various MMPs were carried out as described by Devel et al. (Devel et ...More data for this Ligand-Target Pair