BDBM93423 PHD Inhibitor, 12{2,3,2}::PHD Inhibitor, 12{2,4,2}

SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1

InChI Key InChIKey=MUUFKPHKUZXIMS-CLJLJLNGSA-N

Data  6 IC50

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 93423   

TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen Inc

LigandPNGBDBM93423(PHD Inhibitor, 12{2,3,2} | PHD Inhibitor, 12{2,4,2...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C34H35N5O8/c1-20(40)37-26(17-22-11-7-4-8-12-22)32(45)38-25(16-21-9-5-3-6-10-21)31(44)35-18-23-13-14-27-24(15-23)30(43)29(34(47)39(27)2)33(46)36-19-28(41)42/h3-15,25-26,43H,16-19H2,1-2H3,(H,35,44)(H,36,46)(H,37,40)(H,38,45)(H,41,42)/t25-,26-/m1/s1
Affinity DataIC50: 37.4nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
TargetEgl nine homolog 1(Homo sapiens (Human))
Amgen Inc

LigandPNGBDBM93423(PHD Inhibitor, 12{2,3,2} | PHD Inhibitor, 12{2,4,2...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C34H35N5O8/c1-20(40)37-26(17-22-11-7-4-8-12-22)32(45)38-25(16-21-9-5-3-6-10-21)31(44)35-18-23-13-14-27-24(15-23)30(43)29(34(47)39(27)2)33(46)36-19-28(41)42/h3-15,25-26,43H,16-19H2,1-2H3,(H,35,44)(H,36,46)(H,37,40)(H,38,45)(H,41,42)/t25-,26-/m1/s1
Affinity DataIC50: 90.2nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Amgen Inc

LigandPNGBDBM93423(PHD Inhibitor, 12{2,3,2} | PHD Inhibitor, 12{2,4,2...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C34H35N5O8/c1-20(40)37-26(17-22-11-7-4-8-12-22)32(45)38-25(16-21-9-5-3-6-10-21)31(44)35-18-23-13-14-27-24(15-23)30(43)29(34(47)39(27)2)33(46)36-19-28(41)42/h3-15,25-26,43H,16-19H2,1-2H3,(H,35,44)(H,36,46)(H,37,40)(H,38,45)(H,41,42)/t25-,26-/m1/s1
Affinity DataIC50: 13.5nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Amgen Inc

LigandPNGBDBM93423(PHD Inhibitor, 12{2,3,2} | PHD Inhibitor, 12{2,4,2...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C34H35N5O8/c1-20(40)37-26(17-22-11-7-4-8-12-22)32(45)38-25(16-21-9-5-3-6-10-21)31(44)35-18-23-13-14-27-24(15-23)30(43)29(34(47)39(27)2)33(46)36-19-28(41)42/h3-15,25-26,43H,16-19H2,1-2H3,(H,35,44)(H,36,46)(H,37,40)(H,38,45)(H,41,42)/t25-,26-/m1/s1
Affinity DataIC50: 12.2nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN3(Homo sapiens (Human))
Amgen Inc

LigandPNGBDBM93423(PHD Inhibitor, 12{2,3,2} | PHD Inhibitor, 12{2,4,2...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C34H35N5O8/c1-20(40)37-26(17-22-11-7-4-8-12-22)32(45)38-25(16-21-9-5-3-6-10-21)31(44)35-18-23-13-14-27-24(15-23)30(43)29(34(47)39(27)2)33(46)36-19-28(41)42/h3-15,25-26,43H,16-19H2,1-2H3,(H,35,44)(H,36,46)(H,37,40)(H,38,45)(H,41,42)/t25-,26-/m1/s1
Affinity DataIC50: 11.7nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Amgen Inc

LigandPNGBDBM93423(PHD Inhibitor, 12{2,3,2} | PHD Inhibitor, 12{2,4,2...)
Show SMILES CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCc1ccc2n(C)c(=O)c(C(=O)NCC(O)=O)c(O)c2c1
Show InChI InChI=1S/C34H35N5O8/c1-20(40)37-26(17-22-11-7-4-8-12-22)32(45)38-25(16-21-9-5-3-6-10-21)31(44)35-18-23-13-14-27-24(15-23)30(43)29(34(47)39(27)2)33(46)36-19-28(41)42/h3-15,25-26,43H,16-19H2,1-2H3,(H,35,44)(H,36,46)(H,37,40)(H,38,45)(H,41,42)/t25-,26-/m1/s1
Affinity DataIC50: 7.20nMAssay Description:PHD1,2,3 activity was measured utilizing homogeneous time-resolved fluroescence energy transfer techology by detecting the trans-4-hydroxylatio of HI...More data for this Ligand-Target Pair